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Interaction Between the Matrix Protein and the Polymerase Complex of Respiratory Syncytial Virus.

Viruses - 4 Dec 2024

Atchison Elliot B, Croft Sarah N, Mathew Cynthia, Brookes Daniel W, Coates Matthew, Ito Kazuhiro, Ghildyal Reena

Abstract excerpt

The global burden of respiratory syncytial virus (RSV) and severe associated disease is prodigious. RSV-specific vaccines have been launched recently but there is no antiviral medicine commercially available. RSV polymerase (L) protein is one of the promising antiviral targets, along with fusion and nucleocapsid proteins. During medicinal chemistry campaigns, two potent L-protein inhibitors (PC786 and PC751) were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39772190
DOI: 10.3390/v16121881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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