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Reversible disruption of XPO1-mediated nuclear export inhibits respiratory syncytial virus (RSV) replication

28 Sept 2021

Abstract excerpt

Respiratory syncytial virus (RSV) is the primary cause of serious lower respiratory tract disease in infants, young children, the elderly and immunocompromised individuals. Therapy for RSV infections is limited to high risk infants and there are no safe and efficacious vaccines. Matrix (M) protein is a major RSV structural protein with a key role in virus assembly. Interestingly, M is localised to the nucleus...

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PMID: 34584169
DOI: 10.1038/s41598-021-98767-2

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