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Article

ELTD1 Activation Induces an Endothelial-EMT Transition to a Myofibroblast Phenotype.

International journal of molecular sciences - 19 Oct 2021

Sheldon Helen, Alexander John, Bridges Esther, Moreira Lucia, Reilly Svetlana, Ang Koon Hwee, Wang Dian, Lin Salwa, Haider Syed, Banham Alison H, Harris Adrian L

Abstract excerpt

ELTD1 is expressed in endothelial and vascular smooth muscle cells and has a role in angiogenesis. It has been classified as an adhesion GPCR, but as yet, no ligand has been identified and its function remains unknown. To establish its role, ELTD1 was overexpressed in endothelial cells. Expression and consequently ligand independent activation of ELTD1 results in endothelial-mesenchymal transistion (EndMT) with a...

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Source

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Identifiers

PMID: 34681953
DOI: 10.3390/ijms222011293
PMCID: PMC8539764

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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