A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis.

doi:10.1016/j.ccr.2013.06.004

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Article

A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis.

Cancer cell - 12 Aug 2013

Masiero Massimo, Simões Filipa Costa, Han Hee Dong, Snell Cameron, Peterkin Tessa, Bridges Esther, Mangala Lingegowda S, Wu Sherry Yen-Yao, Pradeep Sunila, Li Demin, Han Cheng, Dalton Heather, Lopez-Berestein Gabriel, Tuynman Jurriaan B, Mortensen Neil, Li Ji-Liang, Patient Roger, Sood Anil K, Banham Alison H, Harris Adrian L, Buffa Francesca M

Abstract excerpt

Limited clinical benefits derived from anti-VEGF therapy have driven the identification of new targets involved in tumor angiogenesis. Here, we report an integrative meta-analysis to define the transcriptional program underlying angiogenesis in human cancer. This approach identified ELTD1, an orphan G-protein-coupled receptor whose expression is induced by VEGF/bFGF and repressed by DLL4 signaling. Extensive...

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Identifiers

PMID: 23871637
DOI: 10.1016/j.ccr.2013.06.004
PMCID: PMC3743050

Genes

DLL4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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