Article
In-depth molecular analysis of combined and co-primary pulmonary large cell neuroendocrine carcinoma and adenocarcinoma.
International journal of cancer - 1 Mar 2022
Hermans Bregtje C M, Derks Jules L, Hillen Lisa M, van der Baan Irene, van den Broek Esther C, von der Thüsen Jan H, van Suylen Robert-Jan, Atmodimedjo Peggy N, den Toom T Dorine, Coumans-Stallinga Cecile, Timens Wim, Dinjens Winand N M, Dubbink Hendrikus J, Speel Ernst-Jan M, Dingemans Anne-Marie C
Abstract excerpt
Up to 14% of large cell neuroendocrine carcinomas (LCNECs) are diagnosed in continuity with nonsmall cell lung carcinoma. In addition to these combined lesions, 1% to 7% of lung tumors present as co-primary tumors with multiple synchronous lesions. We evaluated molecular and clinicopathological characteristics of combined and co-primary LCNEC-adenocarcinoma (ADC) tumors. Ten patients with LCNEC-ADC (combined) and...
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