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Article

Inbreeding, Native American ancestry and child mortality: linking human selection and paediatric medicine.

Human molecular genetics - 21 Mar 2022

Koenigstein Fabienne, Boekstegers Felix, Wilson James F, Fuentes-Guajardo Macarena, Gonzalez-Jose Rolando, Bedoya Gabriel, Bortolini Maria Cátira, Acuña-Alonzo Victor, Gallo Carla, Ruiz Linares Andres, Rothhammer Francisco, Lorenzo Bermejo Justo

Abstract excerpt

The children of related parents show increased risk of early mortality. The Native American genome typically exhibits long stretches of homozygosity, and Latin Americans are highly heterogeneous regarding the individual burden of homozygosity, the proportion and the type of Native American ancestry. We analysed nationwide mortality and genome-wide genotype data from admixed Chileans to investigate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34673976
DOI: 10.1093/hmg/ddab302
PMCID: PMC8947305

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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