Article
Disease pathways and novel therapeutic targets in hypertrophic cardiomyopathy.
Circulation research - 24 Jun 2011
Ashrafian Houman, McKenna William J, Watkins Hugh
Abstract excerpt
As described in earlier reviews in this series on the molecular basis of hypertrophic cardiomyopathy (HCM), HCM is one of the archetypal monogenic cardiovascular disorders to be understood at the molecular level. Twenty years after the discovery of the first HCM disease gene, genetic studies still confirm that HCM is principally a disease of the sarcomere. At the biophysical level, myofilament mutations generally...
Topics
- Actin Cytoskeleton
- Animals
- Calcium
- Cardiomyopathy, Hypertrophic
- Energy Metabolism
- Humans
- Mutation
- Myocardium
- Signal Transduction