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The genome-wide rate and spectrum of EMS-induced heritable mutations in the microcrustacean Daphnia: on the prospect of forward genetics.

Heredity - 1 Dec 2021

Snyman Marelize, Huynh Trung V, Smith Matthew T, Xu Sen

Abstract excerpt

Forward genetic screening using the alkylating mutagen ethyl methanesulfonate (EMS) is an effective method for identifying phenotypic mutants of interest, which can be further genetically dissected to pinpoint the causal genetic mutations. An accurate estimate of the rate of EMS-induced heritable mutations is fundamental for determining the mutant sample size of a screening experiment that aims to saturate all...

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PMID: 34667306
DOI: 10.1038/s41437-021-00478-x
PMCID: PMC8626432

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