Rare variant association study of veteran twin whole-genomes links severe depression with a nonsynonymous change in the neuronal gene BHLHE22.

doi:10.1080/15622975.2021.1980316

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Article

Rare variant association study of veteran twin whole-genomes links severe depression with a nonsynonymous change in the neuronal gene BHLHE22.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Jan 2000

Hupalo Daniel, Forsberg Christopher W, Goldberg Jack, Kremen William S, Lyons Michael J, Soltis Anthony R, Viollet Coralie, Ursano Robert J, Stein Murray B, Franz Carol E, Sun Yan V, Vaccarino Viola, Smith Nicholas L, Dalgard Clifton L, Wilkerson Matthew D, Pollard Harvey B

Abstract excerpt

OBJECTIVES: Major Depressive Disorder (MDD) is a complex neuropsychiatric disease with known genetic associations, but without known links to rare variation in the human genome. Here we aim to identify rare genetic variants associated with MDD using deep whole-genome sequencing data in an independent population. METHODS: We report the sequencing of 1,688 whole genomes in a large sample of male-male Veteran twins....

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PMID: 34664540
DOI: 10.1080/15622975.2021.1980316
PMCID: PMC9148382

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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