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Article

Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions.

Nature neuroscience - 1 Jul 2021

Levey Daniel F, Stein Murray B, Wendt Frank R, Pathak Gita A, Zhou Hang, Aslan Mihaela, Quaden Rachel, Harrington Kelly M, Nuñez Yaira Z, Overstreet Cassie, Radhakrishnan Krishnan, Sanacora Gerard, McIntosh Andrew M, Shi Jingchunzi, Shringarpure Suyash S, Concato John, Polimanti Renato, Gelernter Joel

Abstract excerpt

Major depressive disorder is the most common neuropsychiatric disorder, affecting 11% of veterans. Here we report results of a large meta-analysis of depression using data from the Million Veteran Program, 23andMe, UK Biobank and FinnGen, including individuals of European ancestry (n = 1,154,267; 340,591 cases) and African ancestry (n = 59,600; 25,843 cases). Transcriptome-wide association study analyses revealed...

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Identifiers

PMID: 34045744
DOI: 10.1038/s41593-021-00860-2
PMCID: PMC8404304

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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