Article
Computer analysis of the relation between hydrogen bond stability in SOD1 mutants and the survival time of amyotrophic lateral sclerosis patients.
Journal of molecular graphics & modelling - 1 Jan 2022
Alemasov Nikolay A, Timofeev Vladimir S, Ivanisenko Nikita V, Kolchanov Nikolay A, Ivanisenko Vladimir A
Abstract excerpt
BACKGROUND AND OBJECTIVE: Mutations in the SOD1 protein can lead to the death of motor neurons, which, in turn, causes an incurable disease called amyotrophic lateral sclerosis (ALS). At the same time, the mechanism of the onset and development of this disease is not fully understood and is often contradictory. METHODS: Accelerated Molecular Dynamics as implemented in the OpenMM library, principal component...
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