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Article

Dynamic properties of SOD1 mutants can predict survival time of patients carrying familial amyotrophic lateral sclerosis.

Journal of biomolecular structure & dynamics - 1 Feb 2017

Alemasov Nikolay A, Ivanisenko Nikita V, Medvedev Sergey P, Zakian Suren M, Kolchanov Nikolay A, Ivanisenko Vladimir A

Abstract excerpt

One of the reasons for the death of motor neurons of the brain and spinal cord in patients with amyotrophic lateral sclerosis is known to be formation of subcellular protein aggregates that are caused by mutations in the SOD1 gene. Patient survival time was earlier shown to have limiting correlation with thermostability change of SOD1 mutant forms of patients' carriers. We hypothesized that aggregation of mutant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26919172
DOI: 10.1080/07391102.2016.1158666

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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