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Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling

14 Oct 2021

Abstract excerpt

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most intractable tumors in the world due to its high rate of recurrence and heterogeneity. Liver cancer initiating cells also called cancer stem cells (CSCs) play a critical role in resistance against typical therapy and high tumor-initiating potential. However, the role of the novel circular RNA (circRNA) circIPO11 in the maintenance of liver cancer...

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PMID: 34649567
DOI: 10.1186/s12943-021-01435-2

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