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hTERT promoter methylation promotes small cell lung cancer progression and radiotherapy resistance

25 Jun 2020

Abstract excerpt

Small cell lung cancer (SCLC) has been a devastating actuality in clinic and the molecular mechanisms underlying this disease remain unclear. The epigenetic alterations located in the promoter region of human telomerase reverse transcriptase (hTERT) have been demonstrated as one of the most prevalent non-coding genomic modifications in multiple cancers. However, alteration of hTERT promoter methylation in SCLC...

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PMID: 32761059
DOI: 10.1093/jrr/rraa052

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