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Article

SIRT3 increases cisplatin sensitivity of small-cell lung cancer through apoptosis.

Gene - 30 Jun 2020

Guo Rui, Li Yang, Xue Yanan, Chen Yingying, Li Jiuling, Deng Xinyue, Su Jing, Liu Yanan, Sun Liankun

Abstract excerpt

Small-cell lung cancer (SCLC) is the most invasive of all lung cancer subtypes, and is characterized by its rapid response to chemotherapy resistance. Overcoming chemotherapy resistance is therefore the key to treating SCLC. P53 is mutated in most SCLCs, which has an effect of enhancing chemotherapy resistance. Regulation of p53 proteins by a variety of post-translational modifications, such as acetylation, which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32229158
DOI: 10.1016/j.gene.2020.144629

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