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Article

Lung metabolome of 1,3-butadiene exposed Collaborative Cross mice reflects metabolic phenotype of human lung cancer.

Toxicology - 1 Nov 2021

Nellis Mary, Caperton Caitlin O, Liu Ken, Tran ViLinh, Go Young-Mi, Hallberg Lance M, Ameredes Bill T, Jones Dean P, Boysen Gunnar

Abstract excerpt

1,3-Butadiene (BD) exposure is known to cause numerous adverse health effects, including cancer, in animals and humans. BD is metabolized to reactive epoxide intermediates, which are genotoxic, but it is not well know what other effects BD has on cellular metabolism. We examined the effects of exposure to BD on the mouse lung metabolome in the genetically heterogeneous collaborative cross outbred mouse model....

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Identifiers

PMID: 34648870
DOI: 10.1016/j.tox.2021.152987
PMCID: PMC9062885

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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