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Article

Genetic Determinants of 1,3-Butadiene Metabolism and Detoxification in Three Populations of Smokers with Different Risks of Lung Cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2017

Boldry Emily J, Patel Yesha M, Kotapati Srikanth, Esades Amanda, Park Sungshim L, Tiirikainen Maarit, Stram Daniel O, Le Marchand Loïc, Tretyakova Natalia

Abstract excerpt

Background: 1,3-Butadiene (BD) is an important carcinogen in tobacco smoke that undergoes metabolic activation to DNA-reactive epoxides. These species can be detoxified via glutathione conjugation and excreted in urine as the corresponding N-acetylcysteine conjugates. We hypothesize that single nucleotide polymorphisms (SNPs) in BD-metabolizing genes may change the balance of BD bioactivation and detoxification...

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Identifiers

PMID: 28292921
DOI: 10.1158/1055-9965.EPI-16-0838
PMCID: PMC5500389

Genes

GSTT1

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