Article
Allele and genotype frequencies of the polymorphic methylenetetrahydrofolate reductase and colorectal cancer among Jordanian population.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2013
Yousef Al-Motassem, Shomaf Maha, Berger Sondra, Ababneh Nidaa, Bobali Yahya, Ali Dema, Al-Hasan Sara, Diab Ola, Ismail Said
Abstract excerpt
BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is involved in DNA synthesis and repair. We here aimed to investigate two common polymorphisms, C677T and A1298C, with genotype and haplotype frequencies in colorectal cancer (CRC) cases among Jordanian. MATERIALS AND METHODS: 131 CRC cases were studied for MTHFR C677T and A1298C polymorphisms, compared to 117 controls taken from the general population,...
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