Article
Susceptibility to ankylosing spondylitis: evidence for the role of ERAP1, TGFb1 and TLR9 gene polymorphisms.
Rheumatology international - 1 Aug 2012
Wu Wenliang, Ding Yan, Chen Yunzhen, Hua Zhao, Liu Haichun, Wang Hongliang, Jiao Guangjun
Abstract excerpt
Genetic factors are thought to be crucial in the pathogenesis of ankylosing spondylitis (AS). Recent studies have reported that ERAP1, TGBβ1 and TLRs genes are likely to have association with AS in different populations. We carried out this study to determine whether single-nucleotide polymorphisms covering the three genes are associated with AS in a Chinese Han population. Genomic DNA was isolated from the...
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