Article
Two-stage case-control study of common ATM gene variants in relation to breast cancer risk.
Breast cancer research and treatment - 1 Nov 2007
Ye Chuanzhong, Dai Qi, Lu Wei, Cai Qiuyin, Zheng Ying, Shu Xiao-Ou, Gu Kai, Gao Yu-Tang, Zheng Wei
Abstract excerpt
The ataxia telangiectasia mutated (ATM) gene is a tumor suppressor gene that plays a critical role in cell cycle arrest, apoptosis, and DNA repair. We evaluated two reported nonsynonymous SNPs (rs1800054 and rs1800058) and three additional common gene variants (rs664143, rs228589, rs1003623) in the ATM gene in relation to breast cancer risk. A two-stage case-control study, using data from the Shanghai Breast...