Article
Clofarabine exerts antileukemic activity against cytarabine-resistant B-cell precursor acute lymphoblastic leukemia with low deoxycytidine kinase expression.
Cancer medicine - 1 Apr 2018
Huang Meixian, Inukai Takeshi, Miyake Kunio, Tanaka Yoichi, Kagami Keiko, Abe Masako, Goto Hiroaki, Minegishi Masayoshi, Iwamoto Shotaro, Sugihara Eiji, Watanabe Atsushi, Somazu Shinpei, Shinohara Tamao, Oshiro Hiroko, Akahane Koshi, Goi Kumiko, Sugita Kanji
Abstract excerpt
Cytosine arabinoside (Ara-C) is one of the key drugs for the treatment of acute myeloid leukemia. It is also used for consolidation therapy of acute lymphoblastic leukemia (ALL). Ara-C is a deoxyadenosine analog and is phosphorylated to form cytosine arabinoside triphosphate (Ara-CTP) as an active form. In the first step of the metabolic pathway, Ara-C is phosphorylated to Ara-CMP by deoxycytidine kinase (DCK)....
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