Differential levels of transcription of p53‐regulated genes by the arginine/proline polymorphism: p53 with arginine at codon 72 favors apoptosis

Abstract excerpt

Human populations contain a functional coding polymorphism (codon 72) in the p53 gene. To explore whether this polymorphism alters the transcriptional pattern of p53-regulated genes, the human isogenic cell lines harboring p53 with either the proline or arginine at codon 72 were employed to activate p53-mediated transcription. Thirty-four p53-regulated genes were assayed for their increased levels of mRNA using...

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