Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alpha-1 Antitrypsin and Hepatocellular Carcinoma in Liver Cirrhosis: SERPINA1 MZ or MS Genotype Carriage Decreases the Risk.

International journal of molecular sciences - 29 Sept 2021

Rabekova Zuzana, Frankova Sona, Jirsa Milan, Neroldova Magdalena, Lunova Mariia, Fabian Ondrej, Kveton Martin, Varys David, Chmelova Klara, Adamkova Vera, Hubacek Jaroslav A, Spicak Julius, Merta Dusan, Sperl Jan

Abstract excerpt

Heterozygotes for Z or S alleles of alpha-1-antrypsin (AAT) have low serum AAT levels. Our aim was to compare the risk of hepatocellular carcinoma (HCC) in patients with liver cirrhosis carrying the SERPINA1 MM, MZ and MS genotypes. The study groups consisted of 1119 patients with liver cirrhosis of various aetiologies, and 3240 healthy individuals served as population controls. The MZ genotype was significantly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha 1-Antitrypsin
Share to Body Mass Index

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carcinoma, Hepatocellular

Share to Gene Frequency

Share to Liver Cirrhosis

Share to Liver Neoplasms

Share to Multivariate Analysis

Share to Sex Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 34638908
DOI: 10.3390/ijms221910560
PMCID: PMC8509047

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alpha-1 Antitrypsin and Hepatocellular Carcinoma in Liver Cirrhosis: SERPINA1 MZ or MS Genotype Carriage Decreases the Risk.PMID 34638908Read ↗

Heterozygosity for the alpha-1-antitrypsin Z allele in cirrhosis is associated with more advanced disease.Semantic proximity Read ↗

Meta-Analysis: Redefining Liver Disease Risk in Heterozygous Alpha-1 Antitrypsin Deficiency.Semantic proximity Read ↗

Association of α 1 Antitrypsin Phenotype and Development of Advanced Liver Disease and Pulmonary Complications Before and After Liver Transplantation.Semantic proximity Read ↗

Heterozygous carriage of the alpha1-antitrypsin Pi*Z variant increases the risk to develop liver cirrhosis.Semantic proximity Read ↗

The Alpha-1 Pi*MZ Genotype Is an Independent Risk Factor for Hepatocellular Carcinoma Development in Patients With ACLD.Semantic proximity Read ↗

Hepatobiliary phenotypes of adults with alpha-1 antitrypsin deficiency.Semantic proximity Read ↗

Does the heterozygous state of alpha-1 antitrypsin deficiency have a role in chronic liver diseases? Interim results of a large case-control study.Semantic proximity Read ↗

Optimal alpha-1 antitrypsin level cutoffs for genotype identification in patients with chronic liver disease.Semantic proximity Read ↗

Z variant heterozygosity in alpha-1 antitrypsin deficiency: disease risk and treatment implications.Semantic proximity Read ↗

Population genetic testing and SERPINA1 sequencing identifies unidentified alpha-1 antitrypsin deficiency alleles and gene-environment interaction with hepatitis C infection.Semantic proximity Read ↗

Aflatoxin-induced TP53 R249S mutation in hepatocellular carcinoma in Thailand: association with tumors developing in the absence of liver cirrhosis.Semantic proximity Read ↗

Heterozygosity for the alpha1-antitrypsin Z allele may confer genetic risk of cholangiocarcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.