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Article

Heterozygosity for the alpha-1-antitrypsin Z allele in cirrhosis is associated with more advanced disease.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society - 1 Jun 2018

Schaefer Benedikt, Mandorfer Mattias, Viveiros André, Finkenstedt Armin, Ferenci Peter, Schneeberger Stefan, Tilg Herbert, Zoller Heinz

Abstract excerpt

Alpha-1-antitrypsin deficiency (A1ATD) due to homozygosity for the Z allele (ZZ) is an established risk factor for cirrhosis, but the liver disease risk in heterozygous Z allele carriers (MZ) is controversial. The aim of the present study was to determine the prevalence of the MZ genotype among patients with cirrhosis and the associated risk of decompensation and liver transplantation/mortality. An unselected...

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Identifiers

PMID: 29573137
DOI: 10.1002/lt.25057
PMCID: PMC6032913

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