Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Optimal alpha-1 antitrypsin level cutoffs for genotype identification in patients with chronic liver disease.

Hepatology communications - 1 Feb 2023

Prakash Sameer, Murali Arvind R

Abstract excerpt

BACKGROUND: Controversy exists whether alpha-1 antitrypsin (A1AT) genotype testing should be performed as a first-line screening for A1AT heterozygous variants. METHODS: We calculated the median and interquartile range of A1AT level for each genotype in 4378 patients with chronic liver disease and "miss rate" of MZ genotype identification at various cutoff levels. FINDINGS: Significant overlap in A1AT level noted...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genotype
Share to Heterozygote
Share to Liver Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 37133851
DOI: 10.1097/HC9.0000000000000023
PMCID: PMC10019232

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Optimal alpha-1 antitrypsin level cutoffs for genotype identification in patients with chronic liver disease.PMID 37133851Read ↗

Does the heterozygous state of alpha-1 antitrypsin deficiency have a role in chronic liver diseases? Interim results of a large case-control study.Semantic proximity Read ↗

Alpha-1 Antitrypsin Deficiency in Patients With Cirrhosis in a US National Cohort.Semantic proximity Read ↗

Causes of altered liver function tests - the role of alpha-1 antitrypsin.Semantic proximity Read ↗

Liver Phenotypes of European Adults Heterozygous or Homozygous for Pi∗Z Variant of AAT (Pi∗MZ vs Pi∗ZZ genotype) and Noncarriers.Semantic proximity Read ↗

Alpha-1 Antitrypsin and Hepatocellular Carcinoma in Liver Cirrhosis: SERPINA1 MZ or MS Genotype Carriage Decreases the Risk.Semantic proximity Read ↗

Association of α 1 Antitrypsin Phenotype and Development of Advanced Liver Disease and Pulmonary Complications Before and After Liver Transplantation.Semantic proximity Read ↗

Genotyping diagnosis of alpha-1 antitrypsin deficiency in Saudi adults with liver cirrhosis.Semantic proximity Read ↗

Population genetic testing and SERPINA1 sequencing identifies unidentified alpha-1 antitrypsin deficiency alleles and gene-environment interaction with hepatitis C infection.Semantic proximity Read ↗

High Prevalence of α‐1‐Antitrypsin Heterozygosity in Children With Chronic Liver DiseaseSemantic proximity Read ↗

The investigation of the frequency of the alpha-1-antitrypsin phenotype in patients with liver cirrhosis.Semantic proximity Read ↗

Clinical and histologic features of adults with alpha-1 antitrypsin deficiency in a non-cirrhotic cohort.Semantic proximity Read ↗

Low yield and utilization of confirmatory testing in a cohort of patients with liver disease assessed for alpha-1 antitrypsin deficiency.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.