Heterozygosity for the alpha1-antitrypsin Z allele may confer genetic risk of cholangiocarcinoma.

doi:10.1111/j.1365-2036.2010.04534.x

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Article

Heterozygosity for the alpha1-antitrypsin Z allele may confer genetic risk of cholangiocarcinoma.

Alimentary pharmacology & therapeutics - 1 Feb 2011

Mihalache F, Höblinger A, Grünhage F, Krawczyk M, Gärtner B C, Acalovschi M, Sauerbruch T, Lammert F, Zimmer V

Abstract excerpt

BACKGROUND: Alpha1-antitrypsin (α1AT) deficiency caused by Z allele homozygosity represents a well-established risk factor for hepatocellular carcinoma. Previous studies have also implicated α1AT Z heterozygosity in cholangiocarcinogenesis. AIM: To assess the 'common' Z and S alleles as well as the promoter variant rs8004738 for association with cholangiocarcinoma. METHODS: We genotyped 182 Caucasian patients and...

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PMID: 21138453
DOI: 10.1111/j.1365-2036.2010.04534.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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