The Alpha-1 Pi*MZ Genotype Is an Independent Risk Factor for Hepatocellular Carcinoma Development in Patients With ACLD.

doi:10.1111/apt.70530

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Article

The Alpha-1 Pi*MZ Genotype Is an Independent Risk Factor for Hepatocellular Carcinoma Development in Patients With ACLD.

Alimentary pharmacology & therapeutics - 1 May 2026

Balcar Lorenz, Semmler Georg, Scheiner Bernhard, Paternostro Rafael, Simbrunner Benedikt, Haunold Tina Jasmin, Jachs Mathias, Hartl Lukas, Hofer Benedikt Silvester, Dominik Nina, Schwarz Michael, Kramer Georg, Sebesta Christian, Thöne Paul, Pinter Matthias, Trauner Michael, Reiberger Thomas, Stättermayer Albert Friedrich, Mandorfer Mattias

Abstract excerpt

BACKGROUND AND AIMS: Homozygosity for the SERPINA1 Pi*Z deficiency allele is the culprit of alpha-1 antitrypsin deficiency-related liver disease, while harbouring a single Z-allele (e.g., the common Pi*MZ genotype) is the strongest genetic risk factor for advanced chronic liver disease (ACLD) and its progression. However, the impact of the Pi*MZ genotype on hepatocellular carcinoma (HCC) development in patients...

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PMID: 41577636
DOI: 10.1111/apt.70530
PMCID: PMC13127851

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SERPINA1

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