Article
NUDT15 polymorphism and NT5C2 and PRPS1 mutations influence thiopurine sensitivity in acute lymphoblastic leukaemia cells.
Journal of cellular and molecular medicine - 1 Nov 2021
Somazu Shinpei, Tanaka Yoichi, Tamai Minori, Watanabe Atsushi, Kagami Keiko, Abe Masako, Harama Daisuke, Shinohara Tamao, Akahane Koshi, Goi Kumiko, Sugita Kanji, Moriyama Takaya, Yang Jun, Goto Hiroaki, Minegishi Masayoshi, Iwamoto Shotaro, Takita Junko, Inukai Takeshi
Abstract excerpt
In chemotherapy for childhood acute lymphoblastic leukaemia (ALL), maintenance therapy consisting of oral daily mercaptopurine and weekly methotrexate is important. NUDT15 variant genotype is reportedly highly associated with severe myelosuppression during maintenance therapy, particularly in Asian and Hispanic populations. It has also been demonstrated that acquired somatic mutations of the NT5C2 and PRPS1...
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