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Article

Susceptibility to 6-MP toxicity conferred by a NUDT15 variant in Japanese children with acute lymphoblastic leukaemia.

British journal of haematology - 1 Oct 2015

Tanaka Yoichi, Kato Motohiro, Hasegawa Daisuke, Urayama Kevin Y, Nakadate Hisaya, Kondoh Kensuke, Nakamura Kozue, Koh Katsuyoshi, Komiyama Takako, Manabe Atsushi

Abstract excerpt

Genotyping of TPMT prior to 6-mercaptopurine (6-MP) administration in acute lymphoblastic leukaemia (ALL) patients has been integrated into clinical practice in some populations of European ancestry. However, the comparable rates of 6-MP myelotoxicity, but rarity of TPMT variants, in Asians suggest that major determinants have yet to be discovered in this population. We genotyped 92 Japanese paediatric ALL...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26033531
DOI: 10.1111/bjh.13518

Genes

NUDT15
TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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