Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IFN-γ mediates Paneth cell death via suppression of mTOR

11 Oct 2021

Abstract excerpt

Paneth cells constitutively produce antimicrobial peptides and growth factors that allow for intestinal homeostasis, host protection, and intestinal stem cell replication. Paneth cells rely heavily on the glycolytic metabolic program, which is in part controlled by the kinase complex Mechanistic target of rapamycin (mTORC1). Yet, little is known about mTOR importance in Paneth cell integrity under steady-state...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to Immune Cell Function and Interaction
Share to PI3K/AKT/mTOR signaling in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34633285
DOI: 10.7554/elife.60478

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IFN-γ mediates Paneth cell death via suppression of mTORPMID 34633285Read ↗

β-catenin driven innate and metabolic reprograming in macrophages fuel T-cells dependent inflammation in Toxoplasma gondii infection: implications for therapeutic interventionSemantic proximity Read ↗

Crohn's disease, autophagy, and the Paneth cell.Semantic proximity Read ↗

The role of IFN-γ in cell-autonomous immune responses against Salmonella Typhimurium and Toxoplasma gondiiSemantic proximity Read ↗

IFN-γ-Induced Intestinal Epithelial Cell-Type-Specific Programmed Cell Death: PANoptosis and Its Modulation in Crohn’s DiseaseSemantic proximity Read ↗

Type I and III interferons synergize with TNF to promote virally-triggered damage to the intestinal epitheliumSemantic proximity Read ↗

Paneth cells and innate mucosal immunitySemantic proximity Read ↗

Exposing Toxoplasma gondii hiding inside the vacuole: a role for GBPs, autophagy and host cell deathSemantic proximity Read ↗

The γδ IEL effector API5 masks genetic susceptibility to Paneth cell death.Semantic proximity Read ↗

The role of autophagy in Paneth cell differentiation and secretion.Semantic proximity Read ↗

Mammalian Target of Rapamycin Inhibition in Trypanosoma cruzi-Infected Macrophages Leads to an Intracellular Profile That Is Detrimental for InfectionSemantic proximity Read ↗

A Combination of Four Nuclear Targeted Effectors Protects <i>Toxoplasma</i> Against Interferon Gamma Driven Human Host Cell Death During Acute InfectionSemantic proximity Read ↗

Intestinal antiviral signaling is controlled by autophagy gene Epg5 independent of the microbiotaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.