Mammalian Target of Rapamycin Inhibition in Trypanosoma cruzi-Infected Macrophages Leads to an Intracellular Profile That Is Detrimental for Infection

Abstract excerpt

Trypanosoma cruzi is the causative agent of Chagas’ disease, which affects approximately 10 million people living mainly in Latin America. Macrophages are one of the first cellular actors confronting the invasion during T. cruzi infection, with their function depending on their proper activation and polarization into distinct M1 and M2 subtypes. Macrophage polarization is thought to be regulated not only by...

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