Article
Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.
Frontiers in endocrinology - 1 Jan 2021
Hescheler Daniel A, Riemann Burkhard, Hartmann Milan J M, Michel Maximilian, Faust Michael, Bruns Christiane J, Alakus Hakan, Chiapponi Costanza
Abstract excerpt
Background: A limited number of targeted therapy options exist for papillary thyroid cancer (PTC) to date. Based on genetic alterations reported by the "The Cancer Genome Atlas (TCGA)", we explored whether PTC shows alterations that may be targetable by drugs approved by the FDA for other solid cancers. Methods: Databases of the National Cancer Institute and MyCancerGenome were screened to identify FDA-approved...
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