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Molecular Genetic Techniques for the Proteoglycan Functions in Drosophila.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2022

Bowden Nanako, Takemura Masahiko, Nakato Hiroshi

Abstract excerpt

Several classes of heparan sulfate proteoglycan (HSPG) core proteins and all HS biosynthetic/modifying enzymes are evolutionarily conserved from human to Drosophila melanogaster. This genetically tractable model offers highly sophisticated techniques to manipulate gene function in a spatially and temporally controlled manner. Thus, Drosophila genetics has been a powerful system to explore functions of HSPGs in...

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PMID: 34626396
DOI: 10.1007/978-1-0716-1398-6_32
PMCID: PMC8924912

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