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Genetic characterization of pancreatic cancer patients and prediction of carrier status of germline pathogenic variants in cancer-predisposing genes.

EBioMedicine - 1 Oct 2020

Mizukami Keijiro, Iwasaki Yusuke, Kawakami Eiryo, Hirata Makoto, Kamatani Yoichiro, Matsuda Koichi, Endo Mikiko, Sugano Kokichi, Yoshida Teruhiko, Murakami Yoshinori, Nakagawa Hidewaki, Spurdle Amanda B, Momozawa Yukihide

Abstract excerpt

BACKGROUND: National Comprehensive Cancer Network (NCCN) recently recommended germline genetic testing for all pancreatic cancer patients. However, the genes targeted by genetic testing and the feasibility of selecting patients likely to carry pathogenic variants have not been sufficiently verified. The purpose of this study was to genetically characterize Japanese patients and examine whether the current...

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Identifiers

PMID: 32980694
DOI: 10.1016/j.ebiom.2020.103033
PMCID: PMC7519363

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