Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrative RNA-omics Discovers GNAS Alternative Splicing as a Phenotypic Driver of Splicing Factor-Mutant Neoplasms.

Cancer discovery - 1 Mar 2022

Wheeler Emily C, Vora Shailee, Mayer Daniel, Kotini Andriana G, Olszewska Malgorzata, Park Samuel S, Guccione Ernesto, Teruya-Feldstein Julie, Silverman Lewis, Sunahara Roger K, Yeo Gene W, Papapetrou Eirini P

Abstract excerpt

Mutations in splicing factors (SF) are the predominant class of mutations in myelodysplastic syndrome (MDS), but convergent downstream disease drivers remain elusive. To identify common direct targets of missplicing by mutant U2AF1 and SRSF2, we performed RNA sequencing and enhanced version of the cross-linking and immunoprecipitation assay in human hematopoietic stem/progenitor cells derived from isogenic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromogranins
Share to GTP-Binding Protein alpha Subunits, Gs

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mitogen-Activated Protein Kinase Kinases

Share to Myelodysplastic Syndromes

Share to RNA Splicing

Share to RNA Splicing Factors

Share to Serine-Arginine Splicing Factors

Share to Splicing Factor U2AF

Source

Open in PubMed Open full text

Identifiers

PMID: 34620690
DOI: 10.1158/2159-8290.CD-21-0508
PMCID: PMC8904276

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrative RNA-omics Discovers GNAS Alternative Splicing as a Phenotypic Driver of Splicing Factor-Mutant Neoplasms.PMID 34620690Read ↗

Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations.Semantic proximity Read ↗

Splicing factor mutations in the myelodysplastic syndromes: Role of key aberrantly spliced genes in disease pathophysiology and treatment.Semantic proximity Read ↗

Distinct and convergent consequences of splice factor mutations in myelodysplastic syndromes.Semantic proximity Read ↗

Distinct splicing signatures affect converged pathways in myelodysplastic syndrome patients carrying mutations in different splicing regulators.Semantic proximity Read ↗

SRSF2 mutations drive oncogenesis by activating a global program of aberrant alternative splicing in hematopoietic cells.Semantic proximity Read ↗

Complex landscape of alternative splicing in myeloid neoplasms.Semantic proximity Read ↗

A Unifying Mechanism for Shared Splicing Aberrations in Splicing Factor Mutant CancersSemantic proximity Read ↗

Single-cell multi-omics defines the cell-type specific impact of splicing aberrations in human hematopoietic clonal outgrowthsSemantic proximity Read ↗

Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations.Semantic proximity Read ↗

Splicing factor gene mutations in the myelodysplastic syndromes: impact on disease phenotype and therapeutic applications.Semantic proximity Read ↗

SF3B1-mutant models of RNA mis-splicing uncover UBA1 as a therapeutic target in myelodysplastic neoplasms.Semantic proximity Read ↗

Mechanistic Insights of Aberrant Splicing with Splicing Factor Mutations Found in Myelodysplastic Syndromes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.