Article
Analysis of developmental imprinting dynamics in primates using SNP-free methods to identify imprinting defects in cloned placenta.
Developmental cell - 25 Oct 2021
Chu Chu, Zhang Wenhao, Kang Yu, Si Chenyang, Ji Weizhi, Niu Yuyu, Zhang Yi
Abstract excerpt
Our knowledge of genomic imprinting in primates is lagging behind that of mice largely because of the difficulties of allelic analyses in outbred animals. To understand imprinting dynamics in primates, we profiled transcriptomes, DNA methylomes, and H3K27me3 in uniparental monkey embryos. We further developed single-nucleotide-polymorphism (SNP)-free methods, TARSII and CARSII, to identify germline differentially...
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