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Article

Targeted RNA-seq improves efficiency, resolution, and accuracy of allele specific expression for human term placentas.

G3 (Bethesda, Md.) - 7 Aug 2021

Wu Weisheng, Lovett Jennie L, Shedden Kerby, Strassmann Beverly I, Vincenz Claudius

Abstract excerpt

Genomic imprinting is an epigenetic mechanism that results in allele-specific expression (ASE) based on the parent of origin. It is known to play a role in the prenatal and postnatal allocation of maternal resources in mammals. ASE detected by whole transcriptome RNA-seq (wht-RNAseq) has been widely used to analyze imprinted genes using reciprocal crosses in mice to generate large numbers of informative SNPs....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34009305
DOI: 10.1093/g3journal/jkab176
PMCID: PMC8496276

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