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Human Oocyte-Derived Methylation Differences Persist in the Placenta Revealing Widespread Transient Imprinting

11 Nov 2016

Abstract excerpt

Thousands of regions in gametes have opposing methylation profiles that are largely resolved during the post-fertilization epigenetic reprogramming. However some specific sequences associated with imprinted loci survive this demethylation process. Here we present the data describing the fate of germline-derived methylation in humans. With the exception of a few known paternally methylated germline differentially...

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PMID: 27835649
DOI: 10.1371/journal.pgen.1006427

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