Article
A pan-metazoan concept for adult stem cells: the wobbling Penrose landscape.
Biological reviews of the Cambridge Philosophical Society - 1 Feb 2022
Rinkevich Baruch, Ballarin Loriano, Martinez Pedro, Somorjai Ildiko, Ben-Hamo Oshrat, Borisenko Ilya, Berezikov Eugene, Ereskovsky Alexander, Gazave Eve, Khnykin Denis, Manni Lucia, Petukhova Olga, Rosner Amalia, Röttinger Eric, Spagnuolo Antonietta, Sugni Michela, Tiozzo Stefano, Hobmayer Bert
Abstract excerpt
Adult stem cells (ASCs) in vertebrates and model invertebrates (e.g. Drosophila melanogaster) are typically long-lived, lineage-restricted, clonogenic and quiescent cells with somatic descendants and tissue/organ-restricted activities. Such ASCs are mostly rare, morphologically undifferentiated, and undergo asymmetric cell division. Characterized by 'stemness' gene expression, they can regulate tissue/organ...
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