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Totipotency or plenipotency: rethinking stem cell bipotentiality

18 Mar 2025

Abstract excerpt

The term 'totipotency' has often been misapplied in stem cell research to describe cells with embryonic and extraembryonic bipotentiality, despite a lack of evidence that they can generate an entire organism from a single cell. Additionally, no specific term currently distinguishes bipotential stem cells from pluripotent cells, which contribute poorly to extraembryonic tissues. This review examines the...

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PMID: 40107116
DOI: 10.1016/j.gde.2025.102342

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