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Article

Msx1 haploinsufficiency modifies the Pax9-deficient cardiovascular phenotype.

BMC developmental biology - 6 Oct 2021

Khasawneh Ramada R, Kist Ralf, Queen Rachel, Hussain Rafiqul, Coxhead Jonathan, Schneider Jürgen E, Mohun Timothy J, Zaffran Stéphane, Peters Heiko, Phillips Helen M, Bamforth Simon D

Abstract excerpt

BACKGROUND: Successful embryogenesis relies on the coordinated interaction between genes and tissues. The transcription factors Pax9 and Msx1 genetically interact during mouse craniofacial morphogenesis, and mice deficient for either gene display abnormal tooth and palate development. Pax9 is expressed specifically in the pharyngeal endoderm at mid-embryogenesis, and mice deficient for Pax9 on a C57Bl/6 genetic...

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Identifiers

PMID: 34615475
DOI: 10.1186/s12861-021-00245-5
PMCID: PMC8493722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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