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Article

EZH2 knockout in oral cavity basal epithelia causes more invasive squamous cell carcinomas.

Carcinogenesis - 31 Dec 2021

Baquero Jorge, Tang Xiao-Han, Scognamiglio Theresa, Gudas Lorraine J

Abstract excerpt

Oral squamous cell carcinoma (oral SCC) is an aggressive disease and despite intensive treatments, 5-year survival rates for patients have remained low in the last 20 years. Enhancer of zeste homolog 2 (EZH2), part of polycomb repressive complex 2 (PRC2), is highly expressed in human oral SCC samples and cell lines and has been associated with greater epithelia-to-mesenchymal transition (EMT), invasion and...

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Identifiers

PMID: 34614148
DOI: 10.1093/carcin/bgab091
PMCID: PMC8727743

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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