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Article

The splicing factor Prpf31 is required for hematopoietic stem and progenitor cell expansion during zebrafish embryogenesis.

The Journal of biological chemistry - 1 Mar 2024

Lv Yuexia, Li Jingzhen, Yu Shanshan, Zhang Yangjun, Hu Hualei, Sun Kui, Jia Danna, Han Yunqiao, Tu Jiayi, Huang Yuwen, Liu Xiliang, Zhang Xianghan, Gao Pan, Chen Xiang, Shaw Williams Mark Thomas, Tang Zhaohui, Shu Xinhua, Liu Mugen, Ren Xiang

Abstract excerpt

Pre-mRNA splicing is a precise regulated process and is crucial for system development and homeostasis maintenance. Mutations in spliceosomal components have been found in various hematopoietic malignancies (HMs) and have been considered as oncogenic derivers of HMs. However, the role of spliceosomal components in normal and malignant hematopoiesis remains largely unknown. Pre-mRNA processing factor 31 (PRPF31)...

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Identifiers

PMID: 38382674
DOI: 10.1016/j.jbc.2024.105772
PMCID: PMC10959673

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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