Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The angiotensin I converting enzyme insertion/deletion polymorphism influences therapeutic outcome in major depressed women, but not in men.

Neuroscience letters - 3 Jun 2004

Baghai Thomas C, Schule Cornelius, Zill Peter, Deiml Tobias, Eser Daniela, Zwanzger Peter, Ella Robin, Rupprecht Rainer, Bondy Brigitta

Abstract excerpt

Angiotensin converting enzyme (ACE) is expressed in the central nervous system (CNS), where its primary function comprises degradation of neuropeptides including substance P (SP). Because of the possible antidepressant effects of SP antagonists, the influence of SP on both pathophysiology and mitigation of depression has been hypothesized. It was shown that ACE plasma concentration is determined by an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antidepressive Agents
Share to Chi-Square Distribution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosome Aberrations

Share to Depressive Disorder, Major

Share to Mutagenesis, Insertional

Share to Peptidyl-Dipeptidase A

Share to Psychiatric Status Rating Scales

Share to Sex Characteristics

Source

Identifiers

PMID: 15157992
DOI: 10.1016/j.neulet.2004.03.052

Genes

ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The angiotensin I converting enzyme insertion/deletion polymorphism influences therapeutic outcome in major depressed women, but not in men.PMID 15157992Read ↗

The I/D polymorphism of angiotensin-converting enzyme gene in major depressive disorder and therapeutic outcome: a case-control study and meta-analysis.Semantic proximity Read ↗

Genetic variants in the angiotensin I-converting-enzyme (ACE) and angiotensin II receptor (AT1) gene and clinical outcome in depression.Semantic proximity Read ↗

Association study of angiotensin I-converting enzyme polymorphism and symptomatology and antidepressant response in major depressive disorders.Semantic proximity Read ↗

Influence of ACE gene on differential response to sertraline versus fluoxetine in patients with major depression: a randomized controlled trial.Semantic proximity Read ↗

ACE polymorphism and response to electroconvulsive therapy in major depression.Semantic proximity Read ↗

An insertion/deletion polymorphism in the angiotensin converting enzyme gene is associated with both brain substance P contents and affective disorders.Semantic proximity Read ↗

Impact of ACE2 genetic variant on antidepressant efficacy of SSRIsSemantic proximity Read ↗

Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism.Semantic proximity Read ↗

Insertion/deletion polymorphism in the gene for angiotensin converting enzyme (ACE) in panic disorder: A gender-specific effect?Semantic proximity Read ↗

Insertion/deletion polymorphism of the angiotensin-converting enzyme gene is associated with schizophrenia in a Spanish population.Semantic proximity Read ↗

Hypothalamic-pituitary-adrenocortical axis dysregulation in patients with major depression is influenced by the insertion/deletion polymorphism in the angiotensin I-converting enzyme geneSemantic proximity Read ↗

[Insertion-deletion polymorphism of angiotensin-1-converting enzyme gene in patients with endogenic psychoses].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.