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Article

Computational quantification of global effects induced by mutations and drugs in signaling networks of colorectal cancer cells.

Scientific reports - 1 Oct 2021

Sommariva Sara, Caviglia Giacomo, Ravera Silvia, Frassoni Francesco, Benvenuto Federico, Tortolina Lorenzo, Castagnino Nicoletta, Parodi Silvio, Piana Michele

Abstract excerpt

Colorectal cancer (CRC) is one of the most deadly and commonly diagnosed tumors worldwide. Several genes are involved in its development and progression. The most frequent mutations concern APC, KRAS, SMAD4, and TP53 genes, suggesting that CRC relies on the concomitant alteration of the related pathways. However, with classic molecular approaches, it is not easy to simultaneously analyze the interconnections...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34599254
DOI: 10.1038/s41598-021-99073-7
PMCID: PMC8486743

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