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Diverse CRISPRs Evolving in Human Microbiomes

13 Jun 2012

Abstract excerpt

CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) loci, together with cas (CRISPR-associated) genes, form the CRISPR/Cas adaptive immune system, a primary defense strategy that eubacteria and archaea mobilize against foreign nucleic acids, including phages and conjugative plasmids. Short spacer sequences separated by the repeats are derived from foreign DNA and direct interference to future...

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PMID: 22719260
DOI: 10.1371/journal.pgen.1002441

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