Article
Comparison of mutation profiles in primary melanomas and corresponding nodal naevi using next-generation sequencing.
Clinical and experimental dermatology - 1 Feb 2022
Gambichler T, Rohrmoser E-M, Horny K, Sucker A, Schadendorf D, Skrygan M, Susok L, Stücker M, Becker J C
Abstract excerpt
BACKGROUND: Nodal naevi (NN) represent aggregates of melanocytes within peripheral lymph nodes. NN are relatively often found in patients with malignant melanoma (MM), and may mimic metastatic disease. AIM: To study mutation profiles in MM and NN to find out whether NN descend from a primary MM. METHODS: Next-generation sequencing was performed on formalin-fixed paraffin-embedded tissue of 26 pairs of primary MM...
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