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Rebuilding the microenvironment of primary tumors in humans: a focus on stroma

5 Mar 2024

Abstract excerpt

Conventional tumor models have critical shortcomings in that they lack the complexity of the human stroma. The heterogeneous stroma is a central compartment of the tumor microenvironment (TME) that must be addressed in cancer research and precision medicine. To fully model the human tumor stroma, the deconstruction and reconstruction of tumor tissues have been suggested as new approaches for in vitro tumor...

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PMID: 38443595
DOI: 10.1038/s12276-024-01191-5

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