Article
ATAD2 controls chromatin-bound HIRA turnover.
Life science alliance - 1 Dec 2021
Wang Tao, Perazza Daniel, Boussouar Fayçal, Cattaneo Matteo, Bougdour Alexandre, Chuffart Florent, Barral Sophie, Vargas Alexandra, Liakopoulou Ariadni, Puthier Denis, Bargier Lisa, Morozumi Yuichi, Jamshidikia Mahya, Garcia-Saez Isabel, Petosa Carlo, Rousseaux Sophie, Verdel André, Khochbin Saadi
Abstract excerpt
Taking advantage of the evolutionary conserved nature of ATAD2, we report here a series of parallel functional studies in human, mouse, and Schizosaccharomyces pombe to investigate ATAD2's conserved functions. In S. pombe, the deletion of ATAD2 ortholog, abo1, leads to a dramatic decrease in cell growth, with the appearance of suppressor clones recovering normal growth. The identification of the corresponding...
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