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Article

Evaluating the role of admixture in cancer therapy via in vitro drug response and multivariate genome-wide associations.

Pharmacogenomics - 1 Jan 2015

Jack John, Havener Tammy M, McLeod Howard L, Motsinger-Reif Alison A, Foster Matthew

Abstract excerpt

AIM: We investigate the role of ethnicity and admixture in drug response across a broad group of chemotherapeutic drugs. Also, we generate hypotheses on the genetic variants driving differential drug response through multivariate genome-wide association studies. METHODS: Immortalized lymphoblastoid cell lines from 589 individuals (Hispanic or non-Hispanic/Caucasian) were used to investigate dose-response for 28...

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Antineoplastic Combined Chemotherapy Protocols
Black or African American
Ethnicity
Hispanic or Latino
Multivariate Analysis

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Pharmacogenetics

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PMID: 26314407
DOI: 10.2217/PGS.15.85
PMCID: PMC5810848

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